| Vaccine |
Contraindications |
Precautions |
| Influenza, inactivated (IIV)2 |
Severe allergic reaction (e.g., anaphylaxis) after previous dose of any influenza vaccine; or to a vaccine component, including egg protein |
- Moderate or severe acute illness with or without fever
- History of Guillain-Barré Syndrome within 6 weeks of previous influenza vaccination
- Adults who experience only hives with exposure to eggs may receive RIV or, with additional safety precautions, IIV.2
|
| Influenza, recombinant (RIV) |
Severe allergic reaction (e.g., anaphylaxis) after previous dose of RIV or to a vaccine component. RIV does not contain any egg protein.2 |
- Moderate or severe acute illness with or without fever.
- History of Guillian-Barré Syndrome within 6 weeks of previous influenza vaccination.
|
| Influenza, live attenuated (LAIV)2, 3 |
- Severe allergic reaction (e.g., anaphylaxis) to any component of the vaccine, or to a previous dose of any influenza vaccine
- In addition, ACIP recommends that LAIV not be used in the following populations:
- pregnant women
- immunosuppressed adults
- adults with egg allergy of any severity
- adults who have taken influenza antiviral medications (amantadine, rimantadine, zanamivir, or oseltamivir) within the previous 48 hours; avoid use of these antiviral drugs for 14 days after vaccination
|
- Moderate or severe acute illness with or without fever.
- History of Guillain-Barré Syndrome within 6 weeks of previous influenza vaccination
- Asthma in persons aged 5 years and older
- Other chronic medical conditions, e.g., other chronic lung diseases, chronic cardiovascular disease (excluding isolated hypertension), diabetes, chronic renal or hepatic disease, hematologic disease, neurologic disease, and metabolic disorders
|
| Tetanus, diphtheria, pertussis (Tdap); tetanus, diphtheria (Td) |
- Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component
- For pertussis-containing vaccines: encephalopathy (e.g., coma, decreased level of consciousness, or prolonged seizures) not attributable to another identifiable cause within 7 days of administration of a previous dose of Tdap, diphtheria and tetanus toxoids and pertussis (DTP), or diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine
|
- Moderate or severe acute illness with or without fever
- Guillain-Barré Syndrome within 6 weeks after a previous dose of tetanus toxoid-containing vaccine
- History of Arthus-type hypersensitivity reactions after a previous dose of tetanus or diphtheria toxoid-containing vaccine; defer vaccination until at least 10 years have elapsed since the last tetanus toxoid-containing vaccine
- For pertussis-containing vaccines: progressive or unstable neurologic disorder, uncontrolled seizures, or progressive encephalopathy until a treatment regimen has been established and the condition has stabilized
|
| Varicella3 |
- Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component
- Known severe immunodeficiency (e.g., from hematologic and solid tumors, receipt of chemotherapy, congenital immunodeficiency, or long-term immunosuppressive therapy,4 or patients with human immunodeficiency virus [HIV] infection who are severely immunocompromised)
- Pregnancy
|
- Recent (within 11 months) receipt of antibody-containing blood product (specific interval depends on product)5
- Moderate or severe acute illness with or without fever
- Receipt of specific antivirals (i.e., acyclovir, famciclovir, or valacyclovir) 24 hours before vaccination; avoid use of these antiviral drugs for 14 days after vaccination
|
| Human papillomavirus (HPV) |
Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component. |
- Moderate or severe acute illness with or without fever
- Pregnancy
|
| Zoster3 |
- Severe allergic reaction (e.g., anaphylaxis) to a vaccine component
- Known severe immunodeficiency (e.g., from hematologic and solid tumors, receipt of chemotherapy, or long-term immunosuppressive therapy,4 or patients with HIV infection who are severely immunocompromised)
- Pregnancy
|
- Moderate or severe acute illness with or without fever
- Receipt of specific antivirals (i.e., acyclovir, famciclovir, or valacyclovir) 24 hours before vaccination; avoid use of these antiviral drugs for 14 days after vaccination
|
| Measles, mumps, rubella (MMR)3 |
- Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component
- Known severe immunodeficiency (e.g., from hematologic and solid tumors, receipt of chemotherapy, congenital immunodeficiency, or long-term immunosuppressive therapy,4 or patients with HIV infection who are severely immunocompromised)
- Pregnancy
|
- Moderate or severe acute illness with or without fever
- Recent (within 11 months) receipt of antibody-containing blood product (specific interval depends on product)5
- History of thrombocytopenia or thrombocytopenic purpura
- Need for tuberculin skin testing6
|
| Pneumococcal conjugate (PCV13) |
Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component, including to any vaccine containing diphtheria toxoid. |
Moderate or severe acute illness with or without fever. |
| Pneumococcal polysaccharide (PPSV23) |
Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component. |
Moderate or severe acute illness with or without fever. |
| Meningococcal, conjugate (MenACWY); meningococcal, polysaccharide (MPSV4) |
Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component. |
Moderate or severe acute illness with or without fever. |
| Hepatitis A |
Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component. |
Moderate or severe acute illness with or without fever. |
| Hepatitis B |
Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component. |
Moderate or severe acute illness with or without fever. |
| Haemophilus influenzae Type b (Hib) |
Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component. |
Moderate or severe acute illness with or without fever. |
