Table 5. Statin Drug Characteristics[74] (Open Table in a new window)

high-intensity statin

คือชนิดและขนาดต่อวันของ statin ที่คาดหวังว่าจะลด LDL ลงไปได้ ≥ 50% จาก baseline ได้แก่

atorvastatin 40 - 80 mg
rosuvastatin 20 mg (เราไม่ใช้ 40 mg แล้วนะครับ)

moderate-intensity statin

คือชนิดและขนาดต่อวันของ statin ที่คาดหวังว่าจะลด LDL ลงไปได้เกิน 30 - 50% จาก baseline ได้แก่

simvastatin 20 - 40 mg
atorvastatin 10 - 20 mg
rosuvastatin 5 - 10 mg
pitavastatin 2 - 4 mg
pravastatin 40 - 80 mg
fluvastatin XL 80 mg

√ low-intensity statin

คือชนิดและขนาดต่อวันของ statin ที่คาดหวังว่าจะลด LDL ลงไปได้ < 30% จาก baseline ได้แก่

simvastatin 10 mg
pravastatin 20 - 40 mg
fluvastatin 20 - 40 mg
pitavastatin 1 mg

 

Drug Potency (average LDL decrease) Renal Considerations Liver Function Monitoring
Atorvastatin 10 mg: 35-39%



20 mg: 43%



40 mg: 50%



80 mg: 55-60%



No dose adjustment necessary for reduced renal function Check liver function tests at baseline and when clinically indicated
Fluvastatin 20 mg: 22%



40 mg: 25%



80 mg: 35%



(as XL product)



In severe renal impairment, use daily doses >40 mg with caution Check liver function tests at baseline and when clinically indicated
Lovastatin 10 mg: 21%



20 mg: 24-27%



40 mg: 30-31%



80 mg: 40-42%



(as 40 mg BID)



If CrCl < 30 mL/min, use daily doses over 20 mg with caution Check liver function tests at baseline and when clinically indicated
Pitavastatin 1 mg: 31-32%



2 mg: 36-39%



4 mg: 41-45%



For glomerular filtration rate 15-59 mL/min/1.73 m2, including hemodialysis, initial daily dose is 1 mg, not to exceed 2 mg/day Check liver function tests at baseline and when clinically indicated
Pravastatin 10 mg: 22%



20 mg: 32%



40 mg: 34%



80 mg: 37%



In significant renal impairment, start with 10 mg/day Check liver function tests at baseline and when clinically indicated
Rosuvastatin 5 mg: 45%



10 mg: 46-52%



20 mg: 47-55%



40 mg: 55-63%



If CrCl < 30 mL/min/1.73 m2 (but not on hemodialysis), starting dose is 5 mg/day, not exceed 10 mg/day



Rosuvastatin levels in hemodialysis patients are about 50% higher than levels in normal renal function



Check liver function tests at baseline and when clinically indicated
Simvastatin 5 mg: 26%



10 mg: 30%



20 mg: 38%



40 mg: 29-41%



80 mg: 36-47%



In severe renal impairment, starting dose is 5 mg daily with close monitoring Check liver function tests at baseline and when clinically indicated