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Moderna COVID-19 Vaccine Overview and Safety

Updated June 11, 2021
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CDC Monitoring Reports of Myocarditis and Pericarditis

CDC has received increased reports of myocarditis and pericarditis in adolescents and young adults after COVID-19 vaccination. The known and potential benefits of COVID-19 vaccination outweigh the known and potential risks, including the possible risk of myocarditis or pericarditis. We continue to recommend COVID-19 vaccination for anyone 12 years of age and older.

Learn When to Seek Medical Care

General Information

Name: mRNA-1273

Manufacturer: ModernaTX, Inc.

Type of Vaccine: mRNA

Number of Shots: 2 shots, 28 days apart

How Given: Shot in the muscle of the upper arm

Does NOT Contain: Eggs, preservatives, latex, metals
Full List of Ingredients

Who Should Get Vaccinated
Who Should NOT Get Vaccinated
  • If you have had a severe allergic reaction (anaphylaxis) or an immediate allergic reaction, even if it was not severe, to any ingredient in an mRNA COVID-19 vaccine (such as polyethylene glycol), you should not get an mRNA COVID-19 vaccine.
  • If you had a severe or immediate allergic reaction after getting the first dose of an mRNA COVID-19 vaccine, you should not get a second dose of either of the mRNA COVID-19 vaccines (Moderna or Pfizer-BioNTech).
  • An immediate allergic reaction means a reaction within 4 hours of getting the shot, including symptoms such as hives, swelling, or wheezing (respiratory distress).

If you aren’t able to get an mRNA COVID-19 vaccine, you may still be able to get a different type of COVID-19 vaccine. Get more information for people with allergies.

Possible Side Effects

In the arm where you got the shot:

  • Pain
  • Redness
  • Swelling

Throughout the rest of your body:

  • Tiredness
  • Headache
  • Muscle pain
  • Chills
  • Fever
  • Nausea

These side effects happen within a day or two of getting the vaccine. They are normal signs that your body is building protection and should go away within a few days.

Other Authorized and Recommended COVID-19 Vaccines in the United States.

You should get a COVID-19 vaccination as soon as possible. All currently authorized and recommended COVID-19 vaccines are safe and effective, and CDC does not recommend one vaccine over another.

COVID-19 vaccines are not interchangeable. If you received a Pfizer-BioNTech or Moderna COVID-19 vaccine, you should get the same product for your second shot.

Safety Data Summary

  • In clinical trials, reactogenicity symptoms (side effects that happen within 7 days of getting vaccinated) were common but were mostly mild to moderate. Few people had reactions that affected their ability to do daily activities.
  • Side effects throughout the body (such as fever, chills, tiredness, and headache) were more common after the second dose of the vaccine.
  • CDC will continue to provide updates as we learn more about the safety of the Moderna vaccine in real-world conditions.

Learn more about vaccine safety monitoring after a vaccine is authorized or approved for use.

How Well the Vaccine Works

  • Based on evidence from clinical trials, in people aged 18 years and older, the Moderna vaccine was 94.1% effective at preventing laboratory-confirmed COVID-19 infection in people who received two doses and had no evidence of being previously infected.
  • The vaccine was also highly effective in clinical trials at preventing COVID-19 among people of diverse age, sex, race, and ethnicity categories and among people with underlying medical conditions.
  • CDC will continue to provide updates as we learn more about how well the Moderna vaccine works in real-world conditions.

Clinical Trial Demographic Information

Clinical trials for the Moderna vaccine included people from the following racial, ethnic, age, and sex categories:

Race

  • 79% White
  • 10% African American
  • 5% Asian
  • <3% other races/ethnicities
  • <1% American Indian or Alaska Native
  • <1% Native Hawaiian or Other Pacific Islander

Ethnicity

  • 79% not Hispanic or Latino
  • 20% Hispanic or Latino
  • 1% unknown

Sex

  • 53% male
  • 47% female

Age

  • 75% 18 through 64 years
  • 25% 65 years and older

Twenty-two (22%) of people who participated in the clinical trials had at least one condition that put them at risk of severe illness from COVID-19. The most frequent underlying medical conditions among participants were lung disease, heart disease, obesity, diabetes, liver disease, or HIV infection. Four percent (4%) of participants had two or more high-risk conditions.
Most people who participated in the trials (82%) were considered to have an occupational risk of exposure, with 25% of them being healthcare workers.

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For Healthcare Workers

Moderna COVID-19 Vaccine: General information, schedule and administration overview.